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Anti-NUP98 Monoclonal Antibody (5H871)
(Synonyms: Nup98-96, NUP96, NUP196, ADIR2) Copy Product Info
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Synonyms: Nup98-96, NUP96, NUP196, ADIR2
Catalog No. TMAT-1114 Copy Product Info
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Anti-NUP98 Monoclonal Antibody (5H871) is a Mouse antibody targeting NUP98. Anti-NUP98 Monoclonal Antibody (5H871) can be used in WB,FCM.
Anti-NUP98 Monoclonal Antibody
(5H871)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Stability & Storage
| Description | Anti-NUP98 Monoclonal Antibody (5H871) is a Mouse antibody targeting NUP98. Anti-NUP98 Monoclonal Antibody (5H871) can be used in WB,FCM. |
| Synonyms | Nup98-96, NUP96, NUP196, ADIR2 |
| Ig Type | IgG1 |
| Clone | 5H871 |
| Reactivity | Human,Monkey |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human NUP98 (AA: 1-218) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | NUP98 |
| Gene ID | |
| Protein Name | Nuclear pore complex protein Nup98-Nup96 |
| Uniprot ID |
| Molecular Weight | Theoretical: 197.5 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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