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Anti-MUC16 Monoclonal Antibody (4M881)
(Synonyms: CA125) Copy Product Info
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Synonyms: CA125
Catalog No. TMAT-1445 Copy Product Info
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Anti-MUC16 Monoclonal Antibody (4M881) is a Mouse antibody targeting MUC16. Anti-MUC16 Monoclonal Antibody (4M881) can be used in IHC,FCM.
Anti-MUC16 Monoclonal Antibody
(4M881)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-MUC16 Monoclonal Antibody (4M881) is a Mouse antibody targeting MUC16. Anti-MUC16 Monoclonal Antibody (4M881) can be used in IHC,FCM. |
| Synonyms | CA125 |
| Ig Type | IgG1 |
| Clone | 4M881 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human MUC16 (AA: extra 1-200) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MUC16 |
| Gene ID | |
| Protein Name | Mucin-16 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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