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Synonyms: SCN1, PMN-E, NE, HNE, HLE, GE, ELA2
Anti-ELANE Monoclonal Antibody
(9F435)

| Description | Anti-ELANE Monoclonal Antibody (9F435) is a Mouse antibody targeting ELANE. Anti-ELANE Monoclonal Antibody (9F435) can be used in WB,IHC,FCM. |
| Synonyms | SCN1, PMN-E, NE, HNE, HLE, GE, ELA2 |
| Ig Type | IgG1 |
| Clone | 9F435 |
| Reactivity | Human,Monkey |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | ELANE |
| Gene ID | |
| Protein Name | Neutrophil elastase |
| Uniprot ID |
| Molecular Weight | Theoretical: 28.5 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
| Size | Quantity | Unit Price | Amount | Operation |
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