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Anti-ELANE Monoclonal Antibody (9F435)

(Synonyms: SCN1, PMN-E, NE, HNE, HLE, GE, ELA2) Copy Product Info
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Synonyms: SCN1, PMN-E, NE, HNE, HLE, GE, ELA2

Catalog No. TMAT-0754 Copy Product Info
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Anti-ELANE Monoclonal Antibody (9F435) is a Mouse antibody targeting ELANE. Anti-ELANE Monoclonal Antibody (9F435) can be used in WB,IHC,FCM.

Anti-ELANE Monoclonal Antibody
(9F435)

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Product Introduction

Bioactivity
Description
Anti-ELANE Monoclonal Antibody (9F435) is a Mouse antibody targeting ELANE. Anti-ELANE Monoclonal Antibody (9F435) can be used in WB,IHC,FCM.
SynonymsSCN1, PMN-E, NE, HNE, HLE, GE, ELA2
Ig Type
IgG1
Clone
9F435
Reactivity
Human,Monkey
Application
Recommended Dose
WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationPBS with 0.05% sodium azide
Concentration1 mg/mL
Research BackgroundElastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. Coli.
Antigen Species
Human
Gene Name
ELANE
Gene ID
Protein Name
Neutrophil elastase
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 28.5 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: Anti-ELANE Monoclonal Antibody (9F435) molecular weight