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Anti-HAS2 Monoclonal Antibody (3V153)

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Catalog No. TMAT-1458 Copy Product Info
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Anti-HAS2 Monoclonal Antibody (3V153) is a Mouse antibody targeting HAS2. Anti-HAS2 Monoclonal Antibody (3V153) can be used in WB,IHC,IF.

Anti-HAS2 Monoclonal Antibody
(3V153)

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Product Introduction

Bioactivity
Description
Anti-HAS2 Monoclonal Antibody (3V153) is a Mouse antibody targeting HAS2. Anti-HAS2 Monoclonal Antibody (3V153) can be used in WB,IHC,IF.
Ig Type
IgG1
Clone
3V153
Reactivity
Human,Mouse,Rat,Monkey
Application
Recommended Dose
WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/100-1/500
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationPBS with 0.05% sodium azide
Concentration1 mg/mL
Research BackgroundHyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.
Antigen Species
Human
Gene Name
HAS2
Gene ID
Protein Name
Hyaluronan synthase 2
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 63.5 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: Anti-HAS2 Monoclonal Antibody (3V153) molecular weight