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Anti-GNAS Monoclonal Antibody (3P506)
(Synonyms: POH, PHP1C, PHP1B, PHP1A, NESP, GSP, GSA, GPSA, GNAS1, C20orf45, AHO) Copy Product Info
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Synonyms: POH, PHP1C, PHP1B, PHP1A, NESP, GSP, GSA, GPSA, GNAS1, C20orf45, AHO
Catalog No. TMAT-1166 Copy Product Info
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Anti-GNAS Monoclonal Antibody (3P506) is a Mouse antibody targeting GNAS. Anti-GNAS Monoclonal Antibody (3P506) can be used in IHC,FCM.
Anti-GNAS Monoclonal Antibody
(3P506)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-GNAS Monoclonal Antibody (3P506) is a Mouse antibody targeting GNAS. Anti-GNAS Monoclonal Antibody (3P506) can be used in IHC,FCM. |
| Synonyms | POH, PHP1C, PHP1B, PHP1A, NESP, GSP, GSA, GPSA, GNAS1, C20orf45, AHO |
| Ig Type | IgG2a |
| Clone | 3P506 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012] |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human GNAS (AA: 42-188) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | GNAS |
| Gene ID | |
| Protein Name | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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