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Anti-FAS Monoclonal Antibody (6M108)
(Synonyms: TNFRSF6, FASTM, FAS1, CD95, APT1, APO-1, ALPS1A) Copy Product Info
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Synonyms: TNFRSF6, FASTM, FAS1, CD95, APT1, APO-1, ALPS1A
Catalog No. TMAT-0940 Copy Product Info
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Anti-FAS Monoclonal Antibody (6M108) is a Mouse antibody targeting FAS. Anti-FAS Monoclonal Antibody (6M108) can be used in WB,IF,FCM.
Anti-FAS Monoclonal Antibody
(6M108)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-FAS Monoclonal Antibody (6M108) is a Mouse antibody targeting FAS. Anti-FAS Monoclonal Antibody (6M108) can be used in WB,IF,FCM. |
| Synonyms | TNFRSF6, FASTM, FAS1, CD95, APT1, APO-1, ALPS1A |
| Ig Type | IgG1 |
| Clone | 6M108 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human FAS expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | FAS |
| Gene ID | |
| Protein Name | Tumor necrosis factor receptor superfamily member 6 |
| Uniprot ID |
| Molecular Weight | Theoretical: 37.7 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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