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Anti-HAS1 Monoclonal Antibody (4B42)
(Synonyms: HAS) Copy Product Info
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Synonyms: HAS
Catalog No. TMAT-1462 Copy Product Info
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Anti-HAS1 Monoclonal Antibody (4B42) is a Mouse antibody targeting HAS1. Anti-HAS1 Monoclonal Antibody (4B42) can be used in IF,FCM.
Anti-HAS1 Monoclonal Antibody
(4B42)
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Product Introduction
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Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-HAS1 Monoclonal Antibody (4B42) is a Mouse antibody targeting HAS1. Anti-HAS1 Monoclonal Antibody (4B42) can be used in IF,FCM. |
| Synonyms | HAS |
| Ig Type | IgG2b |
| Clone | 4B42 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human HAS1 (AA: (74-399)) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | HAS1 |
| Gene ID | |
| Protein Name | Hyaluronan synthase 1 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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