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Anti-MLH1 Monoclonal Antibody (6I965)
(Synonyms: HNPCC, FCC2, COCA2) Copy Product Info
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Synonyms: HNPCC, FCC2, COCA2
Catalog No. TMAT-1011 Copy Product Info
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Anti-MLH1 Monoclonal Antibody (6I965) is a Mouse antibody targeting MLH1. Anti-MLH1 Monoclonal Antibody (6I965) can be used in WB,IHC,IF.
Anti-MLH1 Monoclonal Antibody
(6I965)
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-MLH1 Monoclonal Antibody (6I965) is a Mouse antibody targeting MLH1. Anti-MLH1 Monoclonal Antibody (6I965) can be used in WB,IHC,IF. |
| Synonyms | HNPCC, FCC2, COCA2 |
| Ig Type | IgG1 |
| Clone | 6I965 |
| Reactivity | Human,Monkey |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MLH1 |
| Gene ID | |
| Protein Name | DNA mismatch repair protein Mlh1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 85 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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