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Anti-KIR3DL1 Monoclonal Antibody (4R593)
(Synonyms: NKB1B, NKB1, NKAT-3, NKAT3, KIR3DL1/S1, KIR, CD158E1) Copy Product Info
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Synonyms: NKB1B, NKB1, NKAT-3, NKAT3, KIR3DL1/S1, KIR, CD158E1
Catalog No. TMAT-1051 Copy Product Info
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Anti-KIR3DL1 Monoclonal Antibody (4R593) is a Mouse antibody targeting KIR3DL1. Anti-KIR3DL1 Monoclonal Antibody (4R593) can be used in WB,FCM.
Anti-KIR3DL1 Monoclonal Antibody
(4R593)
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-KIR3DL1 Monoclonal Antibody (4R593) is a Mouse antibody targeting KIR3DL1. Anti-KIR3DL1 Monoclonal Antibody (4R593) can be used in WB,FCM. |
| Synonyms | NKB1B, NKB1, NKAT-3, NKAT3, KIR3DL1/S1, KIR, CD158E1 |
| Ig Type | IgG2b |
| Clone | 4R593 |
| Reactivity | Human,Rat |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human KIR3DL1 (AA: extra 22-340) expressed in HEK293 cells. |
| Antigen Species | Human |
| Gene Name | KIR3DL1 |
| Gene ID | |
| Protein Name | Killer cell immunoglobulin-like receptor 3DL1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 49 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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