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Anti-PIRH2 Monoclonal Antibody (1K622)
(Synonyms: ZNF363, ZCHY, RNF199, RCHY1, PRO1996, CHIMP, ARNIP) Copy Product Info
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Synonyms: ZNF363, ZCHY, RNF199, RCHY1, PRO1996, CHIMP, ARNIP
Catalog No. TMAT-1493 Copy Product Info
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Anti-PIRH2 Monoclonal Antibody (1K622) is a Mouse antibody targeting PIRH2. Anti-PIRH2 Monoclonal Antibody (1K622) can be used in WB,IHC,IF,FCM.
Anti-PIRH2 Monoclonal Antibody
(1K622)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Stability & Storage
| Description | Anti-PIRH2 Monoclonal Antibody (1K622) is a Mouse antibody targeting PIRH2. Anti-PIRH2 Monoclonal Antibody (1K622) can be used in WB,IHC,IF,FCM. |
| Synonyms | ZNF363, ZCHY, RNF199, RCHY1, PRO1996, CHIMP, ARNIP |
| Ig Type | IgG1 |
| Clone | 1K622 |
| Reactivity | Human,Rat |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | PIRH2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human Pirh2 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | RCHY1 |
| Gene ID | |
| Protein Name | RING finger and CHY zinc finger domain-containing protein 1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 30; 60 kDa (homodimer). |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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