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Anti-FLT3 Monoclonal Antibody (1E870)
(Synonyms: STK1, FLK-2, FLK2, CD135) Copy Product Info
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Synonyms: STK1, FLK-2, FLK2, CD135
Catalog No. TMAT-1003 Copy Product Info
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Anti-FLT3 Monoclonal Antibody (1E870) is a Mouse antibody targeting FLT3. Anti-FLT3 Monoclonal Antibody (1E870) can be used in IHC.
Anti-FLT3 Monoclonal Antibody
(1E870)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-FLT3 Monoclonal Antibody (1E870) is a Mouse antibody targeting FLT3. Anti-FLT3 Monoclonal Antibody (1E870) can be used in IHC. |
| Synonyms | STK1, FLK-2, FLK2, CD135 |
| Ig Type | IgG1 |
| Clone | 1E870 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | FLT3 |
| Gene ID | |
| Protein Name | Receptor-type tyrosine-protein kinase FLT3 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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