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Anti-PMS2 Monoclonal Antibody (7W250)
(Synonyms: PMSL2, PMS2CL, MLH4, HNPCC4) Copy Product Info
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Synonyms: PMSL2, PMS2CL, MLH4, HNPCC4
Catalog No. TMAT-1119 Copy Product Info
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Anti-PMS2 Monoclonal Antibody (7W250) is a Mouse antibody targeting PMS2. Anti-PMS2 Monoclonal Antibody (7W250) can be used in IHC,FCM.
Anti-PMS2 Monoclonal Antibody
(7W250)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-PMS2 Monoclonal Antibody (7W250) is a Mouse antibody targeting PMS2. Anti-PMS2 Monoclonal Antibody (7W250) can be used in IHC,FCM. |
| Synonyms | PMSL2, PMS2CL, MLH4, HNPCC4 |
| Ig Type | IgG1 |
| Clone | 7W250 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human PMS2 (AA: (431-580)) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | PMS2 |
| Gene ID | |
| Protein Name | Mismatch repair endonuclease PMS2 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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