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Anti-E7 Monoclonal Antibody (5H750)
(Synonyms: HpV16gp2, E7) Copy Product Info
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Synonyms: HpV16gp2, E7
Catalog No. TMAT-0671 Copy Product Info
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Anti-E7 Monoclonal Antibody (5H750) is a Mouse antibody targeting E7. Anti-E7 Monoclonal Antibody (5H750) can be used in IHC.
Anti-E7 Monoclonal Antibody
(5H750)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-E7 Monoclonal Antibody (5H750) is a Mouse antibody targeting E7. Anti-E7 Monoclonal Antibody (5H750) can be used in IHC. |
| Synonyms | HpV16gp2, E7 |
| Ig Type | IgG1 |
| Clone | 5H750 |
| Reactivity | Virus |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of E7 expressed in E. Coli. |
| Antigen Species | Virus |
| Gene Name | E7 |
| Gene ID | |
| Protein Name | Protein E7 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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