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Anti-SORL1 Monoclonal Antibody (3M860)
(Synonyms: SORL1) Copy Product Info
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Synonyms: SORL1
Catalog No. TMAT-1454 Copy Product Info
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Anti-SORL1 Monoclonal Antibody (3M860) is a Mouse antibody targeting SORL1. Anti-SORL1 Monoclonal Antibody (3M860) can be used in IHC,IF.
Anti-SORL1 Monoclonal Antibody
(3M860)
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Product Introduction
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| Description | Anti-SORL1 Monoclonal Antibody (3M860) is a Mouse antibody targeting SORL1. Anti-SORL1 Monoclonal Antibody (3M860) can be used in IHC,IF. |
| Synonyms | SORL1 |
| Ig Type | IgG1 |
| Clone | 3M860 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; IF: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human SORL1 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | SORL1 |
| Gene ID | |
| Protein Name | Sortilin-related receptor |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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