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Anti-GRIA2 Monoclonal Antibody (5X785)
(Synonyms: HBGR2, GluR-K2, GLURB, GLUR2, GluA2) Copy Product Info
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Synonyms: HBGR2, GluR-K2, GLURB, GLUR2, GluA2
Catalog No. TMAT-1028 Copy Product Info
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Anti-GRIA2 Monoclonal Antibody (5X785) is a Mouse antibody targeting GRIA2. Anti-GRIA2 Monoclonal Antibody (5X785) can be used in IHC,FCM.
Anti-GRIA2 Monoclonal Antibody
(5X785)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-GRIA2 Monoclonal Antibody (5X785) is a Mouse antibody targeting GRIA2. Anti-GRIA2 Monoclonal Antibody (5X785) can be used in IHC,FCM. |
| Synonyms | HBGR2, GluR-K2, GLURB, GLUR2, GluA2 |
| Ig Type | IgG2b |
| Clone | 5X785 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human GRIA2 (AA: 35-175) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | GRIA2 |
| Gene ID | |
| Protein Name | Glutamate receptor 2 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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