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Anti-VEGFA Monoclonal Antibody (7R403)
(Synonyms: VPF, VEGF, MVCD1) Copy Product Info
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Synonyms: VPF, VEGF, MVCD1
Catalog No. TMAT-0854 Copy Product Info
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Anti-VEGFA Monoclonal Antibody (7R403) is a Mouse antibody targeting VEGFA. Anti-VEGFA Monoclonal Antibody (7R403) can be used in WB,FCM.
Anti-VEGFA Monoclonal Antibody
(7R403)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-VEGFA Monoclonal Antibody (7R403) is a Mouse antibody targeting VEGFA. Anti-VEGFA Monoclonal Antibody (7R403) can be used in WB,FCM. |
| Synonyms | VPF, VEGF, MVCD1 |
| Ig Type | IgG1 |
| Clone | 7R403 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human VEGFA (AA: 207-371) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | VEGFA |
| Gene ID | |
| Protein Name | Vascular endothelial growth factor A, long form |
| Uniprot ID |
| Molecular Weight | Theoretical: 27 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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