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Anti-P16 Monoclonal Antibody (4W326)
(Synonyms: TP16, P19ARF, P19, P16-INK4A, P16INK4A, P16INK4, P14ARF, P14, MTS-1, MTS1, MLM, INK4A, INK4, CMM2, CDKN2A, CDKN2, CDK4I, CAI2, ARF) Copy Product Info
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Synonyms: TP16, P19ARF, P19, P16-INK4A, P16INK4A, P16INK4, P14ARF, P14, MTS-1, MTS1, MLM, INK4A, INK4, CMM2, CDKN2A, CDKN2, CDK4I, CAI2, ARF
Catalog No. TMAT-1038 Copy Product Info
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Anti-P16 Monoclonal Antibody (4W326) is a Mouse antibody targeting P16. Anti-P16 Monoclonal Antibody (4W326) can be used in IHC.
Anti-P16 Monoclonal Antibody
(4W326)
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Product Introduction
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| Description | Anti-P16 Monoclonal Antibody (4W326) is a Mouse antibody targeting P16. Anti-P16 Monoclonal Antibody (4W326) can be used in IHC. |
| Synonyms | TP16, P19ARF, P19, P16-INK4A, P16INK4A, P16INK4, P14ARF, P14, MTS-1, MTS1, MLM, INK4A, INK4, CMM2, CDKN2A, CDKN2, CDK4I, CAI2, ARF |
| Ig Type | IgG1 |
| Clone | 4W326 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of P16 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | CDKN2A |
| Gene ID | |
| Protein Name | Cyclin-dependent kinase inhibitor 2A |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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