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Anti-MLL Monoclonal Antibody (3B204)
(Synonyms: MLL) Copy Product Info
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Synonyms: MLL
Catalog No. TMAT-1209 Copy Product Info
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Anti-MLL Monoclonal Antibody (3B204) is a Mouse antibody targeting MLL. Anti-MLL Monoclonal Antibody (3B204) can be used in IHC.
Anti-MLL Monoclonal Antibody
(3B204)
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Related Conjugates and Formulations
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| Description | Anti-MLL Monoclonal Antibody (3B204) is a Mouse antibody targeting MLL. Anti-MLL Monoclonal Antibody (3B204) can be used in IHC. |
| Synonyms | MLL |
| Ig Type | IgG1 |
| Clone | 3B204 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila). Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of MLL (aa3751-3968) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | KMT2A |
| Gene ID | |
| Protein Name | Histone-lysine N-methyltransferase 2A |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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