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Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575)
(Synonyms: PRKM2, PRKM1, P42MAPK, p41mapk, p41, p40, p38, MAPK2, MAPK1, ERT1, ERK2, ERK) Copy Product Info
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Synonyms: PRKM2, PRKM1, P42MAPK, p41mapk, p41, p40, p38, MAPK2, MAPK1, ERT1, ERK2, ERK
Catalog No. TMAT-0961 Copy Product Info
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Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) is a Mouse antibody targeting p44/42 MAPK (Erk1/2). Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) can be used in WB,IHC,IF,FCM.
Anti-p44/42 MAPK
(Erk1/2) Monoclonal Antibody
(6C575)
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| Description | Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) is a Mouse antibody targeting p44/42 MAPK (Erk1/2). Anti-p44/42 MAPK (Erk1/2) Monoclonal Antibody (6C575) can be used in WB,IHC,IF,FCM. |
| Synonyms | PRKM2, PRKM1, P42MAPK, p41mapk, p41, p40, p38, MAPK2, MAPK1, ERT1, ERK2, ERK |
| Ig Type | IgG2b |
| Clone | 6C575 |
| Reactivity | Human,Mouse,Rabbit |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/100-1/500; IF: 1/50-1/500; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human MAPK expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MAPK1 |
| Gene ID | |
| Protein Name | Mitogen-activated protein kinase 1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 42, 44 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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