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Anti-MLH1 Monoclonal Antibody (1T993)
(Synonyms: HNPCC2, HNPCC, hMLH1, FCC2, COCA2) Copy Product Info
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Synonyms: HNPCC2, HNPCC, hMLH1, FCC2, COCA2
Catalog No. TMAT-1012 Copy Product Info
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Anti-MLH1 Monoclonal Antibody (1T993) is a Mouse antibody targeting MLH1. Anti-MLH1 Monoclonal Antibody (1T993) can be used in IF,FCM.
Anti-MLH1 Monoclonal Antibody
(1T993)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-MLH1 Monoclonal Antibody (1T993) is a Mouse antibody targeting MLH1. Anti-MLH1 Monoclonal Antibody (1T993) can be used in IF,FCM. |
| Synonyms | HNPCC2, HNPCC, hMLH1, FCC2, COCA2 |
| Ig Type | IgG2b |
| Clone | 1T993 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human MLH1 (AA: 381-483) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MLH1 |
| Gene ID | |
| Protein Name | DNA mismatch repair protein Mlh1 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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