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Anti-PAX5 Monoclonal Antibody (1M53)
(Synonyms: BSAP) Copy Product Info
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Synonyms: BSAP
Catalog No. TMAT-1204 Copy Product Info
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Anti-PAX5 Monoclonal Antibody (1M53) is a Mouse antibody targeting PAX5. Anti-PAX5 Monoclonal Antibody (1M53) can be used in WB.
Anti-PAX5 Monoclonal Antibody
(1M53)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-PAX5 Monoclonal Antibody (1M53) is a Mouse antibody targeting PAX5. Anti-PAX5 Monoclonal Antibody (1M53) can be used in WB. |
| Synonyms | BSAP |
| Ig Type | IgG1 |
| Clone | 1M53 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | PAX5 |
| Gene ID | |
| Protein Name | Paired box protein Pax-5 |
| Uniprot ID |
| Molecular Weight | Theoretical: 45 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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