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Anti-TLR7 Monoclonal Antibody (9A38)

(Synonyms: TLR7-like, IMD74) Copy Product Info
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Synonyms: TLR7-like, IMD74

Catalog No. TMAT-1593 Copy Product Info
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Anti-TLR7 Monoclonal Antibody (9A38) is a Mouse antibody targeting TLR7. Anti-TLR7 Monoclonal Antibody (9A38) can be used in IF,FCM.

Anti-TLR7 Monoclonal Antibody
(9A38)

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Product Introduction

Bioactivity
Description
Anti-TLR7 Monoclonal Antibody (9A38) is a Mouse antibody targeting TLR7. Anti-TLR7 Monoclonal Antibody (9A38) can be used in IF,FCM.
SynonymsTLR7-like, IMD74
Ig Type
IgG2b
Clone
9A38
Reactivity
Human
Application
Recommended Dose
IF: 1/50-1/200; FCM: 1/200-1/400
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationPBS with 0.05% sodium azide
Concentration1 mg/mL
Research BackgroundThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human TLR7 (AA: 420-644) expressed in E. Coli.
Antigen Species
Human
Gene Name
TLR7
Gene ID
Protein Name
Toll-like receptor 7
Uniprot ID
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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