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Anti-DNMT3L Monoclonal Antibody (8N259)
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Catalog No. TMAT-1623 Copy Product Info
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Anti-DNMT3L Monoclonal Antibody (8N259) is a Mouse antibody targeting DNMT3L. Anti-DNMT3L Monoclonal Antibody (8N259) can be used in FCM.
Anti-DNMT3L Monoclonal Antibody
(8N259)
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-DNMT3L Monoclonal Antibody (8N259) is a Mouse antibody targeting DNMT3L. Anti-DNMT3L Monoclonal Antibody (8N259) can be used in FCM. |
| Ig Type | IgG1 |
| Clone | 8N259 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | DNMT3L |
| Gene ID | |
| Protein Name | DNA (cytosine-5)-methyltransferase 3-like |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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