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Anti-RFA2 Monoclonal Antibody (1G867)
(Synonyms: RP-A p34, RPA2, REPA2, RPA32, RPA34) Copy Product Info
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Synonyms: RP-A p34, RPA2, REPA2, RPA32, RPA34
Catalog No. TMAT-0858 Copy Product Info
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Anti-RFA2 Monoclonal Antibody (1G867) is a Mouse antibody targeting RFA2. Anti-RFA2 Monoclonal Antibody (1G867) can be used in WB,IHC,FCM.
Anti-RFA2 Monoclonal Antibody
(1G867)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-RFA2 Monoclonal Antibody (1G867) is a Mouse antibody targeting RFA2. Anti-RFA2 Monoclonal Antibody (1G867) can be used in WB,IHC,FCM. |
| Synonyms | RP-A p34, RPA2, REPA2, RPA32, RPA34 |
| Ig Type | IgG1 |
| Clone | 1G867 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human RFA2 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | RPA2 |
| Gene ID | |
| Protein Name | Replication protein A 32 kDa subunit |
| Uniprot ID |
| Molecular Weight | Theoretical: 29 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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