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Synonyms: Raf-1, NS5, c-Raf, CRAF
Anti-RAF1 Monoclonal Antibody
(4K700)

| Description | Anti-RAF1 Monoclonal Antibody (4K700) is a Mouse antibody targeting RAF1. Anti-RAF1 Monoclonal Antibody (4K700) can be used in WB,IHC,FCM. |
| Synonyms | Raf-1, NS5, c-Raf, CRAF |
| Ig Type | IgG1 |
| Clone | 4K700 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human RAF1 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | RAF1 |
| Gene ID | |
| Protein Name | RAF proto-oncogene serine/threonine-protein kinase |
| Uniprot ID |
| Molecular Weight | Theoretical: 73 kDa |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
| Size | Quantity | Unit Price | Amount | Operation |
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