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Anti-RAN Monoclonal Antibody (9S993)
(Synonyms: TC4, Gsp1, ARA24) Copy Product Info
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Synonyms: TC4, Gsp1, ARA24
Catalog No. TMAT-1162 Copy Product Info
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Anti-RAN Monoclonal Antibody (9S993) is a Mouse antibody targeting RAN. Anti-RAN Monoclonal Antibody (9S993) can be used in WB,IHC,IF,FCM.
Anti-RAN Monoclonal Antibody
(9S993)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Stability & Storage
| Description | Anti-RAN Monoclonal Antibody (9S993) is a Mouse antibody targeting RAN. Anti-RAN Monoclonal Antibody (9S993) can be used in WB,IHC,IF,FCM. |
| Synonyms | TC4, Gsp1, ARA24 |
| Ig Type | IgG1 |
| Clone | 9S993 |
| Reactivity | Human,Mouse,Monkey,Rat |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human RAN (AA: 1-216) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | RAN |
| Gene ID | |
| Protein Name | GTP-binding nuclear protein Ran |
| Uniprot ID |
| Molecular Weight | Theoretical: 24.4 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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