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Anti-ROR1 Monoclonal Antibody (2M499)
(Synonyms: NTRKR1, dJ537F10.1) Copy Product Info
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Synonyms: NTRKR1, dJ537F10.1
Catalog No. TMAT-1197 Copy Product Info
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Anti-ROR1 Monoclonal Antibody (2M499) is a Mouse antibody targeting ROR1. Anti-ROR1 Monoclonal Antibody (2M499) can be used in IF.
Anti-ROR1 Monoclonal Antibody
(2M499)
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Product Introduction
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| Description | Anti-ROR1 Monoclonal Antibody (2M499) is a Mouse antibody targeting ROR1. Anti-ROR1 Monoclonal Antibody (2M499) can be used in IF. |
| Synonyms | NTRKR1, dJ537F10.1 |
| Ig Type | IgG1 |
| Clone | 2M499 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IF: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells |
| Antigen Species | Human |
| Gene Name | ROR1 |
| Gene ID | |
| Protein Name | Inactive tyrosine-protein kinase transmembrane receptor ROR1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 101 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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