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Anti-IGF1R-Beta Monoclonal Antibody (8J90)
(Synonyms: IGF1R) Copy Product Info
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Synonyms: IGF1R
Catalog No. TMAT-0748 Copy Product Info
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Anti-IGF1R-Beta Monoclonal Antibody (8J90) is a Mouse antibody targeting IGF1R-Beta. Anti-IGF1R-Beta Monoclonal Antibody (8J90) can be used in IHC.
Anti-IGF1R-Beta Monoclonal Antibody
(8J90)
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| Description | Anti-IGF1R-Beta Monoclonal Antibody (8J90) is a Mouse antibody targeting IGF1R-Beta. Anti-IGF1R-Beta Monoclonal Antibody (8J90) can be used in IHC. |
| Synonyms | IGF1R |
| Ig Type | IgG2a |
| Clone | 8J90 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | IGF1R |
| Gene ID | |
| Protein Name | Insulin-like growth factor 1 receptor |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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