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Anti-IGHM Monoclonal Antibody (2R959)
(Synonyms: VH, MU, AGM1) Copy Product Info
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Synonyms: VH, MU, AGM1
Catalog No. TMAT-0645 Copy Product Info
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Anti-IGHM Monoclonal Antibody (2R959) is a Mouse antibody targeting IGHM. Anti-IGHM Monoclonal Antibody (2R959) can be used in WB,IHC,FCM.
Anti-IGHM Monoclonal Antibody
(2R959)
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| Description | Anti-IGHM Monoclonal Antibody (2R959) is a Mouse antibody targeting IGHM. Anti-IGHM Monoclonal Antibody (2R959) can be used in WB,IHC,FCM. |
| Synonyms | VH, MU, AGM1 |
| Ig Type | IgG1 |
| Clone | 2R959 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005). |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | IGHM |
| Gene ID | |
| Protein Name | Immunoglobulin heavy constant mu |
| Uniprot ID |
| Molecular Weight | Theoretical: 49.3 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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