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Synonyms: VLC1, MLC1V, MLC1SB, CMH8
Anti-MYL3 Monoclonal Antibody
(2V387)

| Description | Anti-MYL3 Monoclonal Antibody (2V387) is a Mouse antibody targeting MYL3. Anti-MYL3 Monoclonal Antibody (2V387) can be used in WB,IHC. |
| Synonyms | VLC1, MLC1V, MLC1SB, CMH8 |
| Ig Type | IgG1 |
| Clone | 2V387 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of MYL3 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MYL3 |
| Gene ID | |
| Protein Name | Myosin light chain 3 |
| Uniprot ID |
| Molecular Weight | Theoretical: 22 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
| Size | Quantity | Unit Price | Amount | Operation |
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