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Anti-HLA-B Monoclonal Antibody (4C830)
(Synonyms: SPDA1, HLA-Cw, HLAB, Bw-50, Bw-47, B-5001, B-4901, AS) Copy Product Info
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Synonyms: SPDA1, HLA-Cw, HLAB, Bw-50, Bw-47, B-5001, B-4901, AS
Catalog No. TMAT-0647 Copy Product Info
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Anti-HLA-B Monoclonal Antibody (4C830) is a Mouse antibody targeting HLA-B. Anti-HLA-B Monoclonal Antibody (4C830) can be used in WB,IHC,IF,FCM.
Anti-HLA-B Monoclonal Antibody
(4C830)
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Product Introduction
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| Description | Anti-HLA-B Monoclonal Antibody (4C830) is a Mouse antibody targeting HLA-B. Anti-HLA-B Monoclonal Antibody (4C830) can be used in WB,IHC,IF,FCM. |
| Synonyms | SPDA1, HLA-Cw, HLAB, Bw-50, Bw-47, B-5001, B-4901, AS |
| Ig Type | IgG1 |
| Clone | 4C830 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human HLA-B (AA: 241-362) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | HLA-B |
| Gene ID | |
| Protein Name | HLA class I histocompatibility antigen, B alpha chain |
| Uniprot ID |
| Molecular Weight | Theoretical: 40.5 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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