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Anti-IKZF1 Monoclonal Antibody (5F492)
(Synonyms: ZNFN1A1, PRO0758, PPP1R92, LyF-1, LYF1, IKAROS, IK1, Hs.54452, CVID13) Copy Product Info
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Synonyms: ZNFN1A1, PRO0758, PPP1R92, LyF-1, LYF1, IKAROS, IK1, Hs.54452, CVID13
Catalog No. TMAT-1275 Copy Product Info
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Anti-IKZF1 Monoclonal Antibody (5F492) is a Mouse antibody targeting IKZF1. Anti-IKZF1 Monoclonal Antibody (5F492) can be used in IF,FCM.
Anti-IKZF1 Monoclonal Antibody
(5F492)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-IKZF1 Monoclonal Antibody (5F492) is a Mouse antibody targeting IKZF1. Anti-IKZF1 Monoclonal Antibody (5F492) can be used in IF,FCM. |
| Synonyms | ZNFN1A1, PRO0758, PPP1R92, LyF-1, LYF1, IKAROS, IK1, Hs.54452, CVID13 |
| Ig Type | IgG2b |
| Clone | 5F492 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human IKZF1 (AA: 401-520) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | IKZF1 |
| Gene ID | |
| Protein Name | DNA-binding protein Ikaros |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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