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Anti-E2F1 Monoclonal Antibody (3Z145)

(Synonyms: RBP3, RBBP3, RBAP1, E2F-1) Copy Product Info
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Synonyms: RBP3, RBBP3, RBAP1, E2F-1

Catalog No. TMAT-1188 Copy Product Info
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Anti-E2F1 Monoclonal Antibody (3Z145) is a Mouse antibody targeting E2F1. Anti-E2F1 Monoclonal Antibody (3Z145) can be used in WB,IHC,FCM.

Anti-E2F1 Monoclonal Antibody
(3Z145)

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Product Introduction

Bioactivity
Description
Anti-E2F1 Monoclonal Antibody (3Z145) is a Mouse antibody targeting E2F1. Anti-E2F1 Monoclonal Antibody (3Z145) can be used in WB,IHC,FCM.
SynonymsRBP3, RBBP3, RBAP1, E2F-1
Ig Type
IgG1
Clone
3Z145
Reactivity
Human,Mouse
Application
Recommended Dose
WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationPBS with 0.05% sodium azide
Concentration1 mg/mL
Research BackgroundThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human E2F1 (AA: 69-223) expressed in E. Coli.
Antigen Species
Human
Gene Name
E2F1
Gene ID
Protein Name
Transcription factor E2F1
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 46.9 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: Anti-E2F1 Monoclonal Antibody (3Z145) molecular weight