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Anti-PYK2 Monoclonal Antibody (6M943)

(Synonyms: PTK2B, PTK, PKB, FRNK, FAK2, CAKB) Copy Product Info
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Synonyms: PTK2B, PTK, PKB, FRNK, FAK2, CAKB

Catalog No. TMAT-1303 Copy Product Info
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Anti-PYK2 Monoclonal Antibody (6M943) is a Mouse antibody targeting PYK2. Anti-PYK2 Monoclonal Antibody (6M943) can be used in WB,IHC.

Anti-PYK2 Monoclonal Antibody
(6M943)

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Product Introduction

Bioactivity
Description
Anti-PYK2 Monoclonal Antibody (6M943) is a Mouse antibody targeting PYK2. Anti-PYK2 Monoclonal Antibody (6M943) can be used in WB,IHC.
SynonymsPTK2B, PTK, PKB, FRNK, FAK2, CAKB
Ig Type
IgG2a
Clone
6M943
Reactivity
Human
Application
Recommended Dose
WB: 1/500-1/2000; IHC: 1/200-1/1000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationAscitic fluid containing 0.03% sodium azide.
Concentration1 mg/mL
Research BackgroundPYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
Antigen Species
Human
Gene Name
PTK2B
Gene ID
Protein Name
Protein-tyrosine kinase 2-beta
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 115.8 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: Anti-PYK2 Monoclonal Antibody (6M943) molecular weight