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Anti-VAV1 Monoclonal Antibody (8R399)
(Synonyms: VAV) Copy Product Info
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Synonyms: VAV
Catalog No. TMAT-0849 Copy Product Info
😃Good
Anti-VAV1 Monoclonal Antibody (8R399) is a Mouse antibody targeting VAV1. Anti-VAV1 Monoclonal Antibody (8R399) can be used in WB,FCM.
Anti-VAV1 Monoclonal Antibody
(8R399)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-VAV1 Monoclonal Antibody (8R399) is a Mouse antibody targeting VAV1. Anti-VAV1 Monoclonal Antibody (8R399) can be used in WB,FCM. |
| Synonyms | VAV |
| Ig Type | IgG1 |
| Clone | 8R399 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | VAV1 |
| Gene ID | |
| Protein Name | Proto-oncogene vav |
| Uniprot ID |
| Molecular Weight | Theoretical: 98.3 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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