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Anti-PAR4 Monoclonal Antibody (8Z790)
(Synonyms: PAWR) Copy Product Info
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Synonyms: PAWR
Catalog No. TMAT-1486 Copy Product Info
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Anti-PAR4 Monoclonal Antibody (8Z790) is a Mouse antibody targeting PAR4. Anti-PAR4 Monoclonal Antibody (8Z790) can be used in IHC.
Anti-PAR4 Monoclonal Antibody
(8Z790)
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-PAR4 Monoclonal Antibody (8Z790) is a Mouse antibody targeting PAR4. Anti-PAR4 Monoclonal Antibody (8Z790) can be used in IHC. |
| Synonyms | PAWR |
| Ig Type | IgG1 |
| Clone | 8Z790 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | PAWR |
| Gene ID | |
| Protein Name | PRKC apoptosis WT1 regulator protein |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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