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Anti-KMT2A Monoclonal Antibody (8N714)
(Synonyms: WDSTS, TRX1, MLL1A, MLL1, MLL, HTRX1, HRX, CXXC7, ALL-1) Copy Product Info
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Synonyms: WDSTS, TRX1, MLL1A, MLL1, MLL, HTRX1, HRX, CXXC7, ALL-1
Catalog No. TMAT-1208 Copy Product Info
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Anti-KMT2A Monoclonal Antibody (8N714) is a Mouse antibody targeting KMT2A. Anti-KMT2A Monoclonal Antibody (8N714) can be used in IHC,IF,FCM.
Anti-KMT2A Monoclonal Antibody
(8N714)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-KMT2A Monoclonal Antibody (8N714) is a Mouse antibody targeting KMT2A. Anti-KMT2A Monoclonal Antibody (8N714) can be used in IHC,IF,FCM. |
| Synonyms | WDSTS, TRX1, MLL1A, MLL1, MLL, HTRX1, HRX, CXXC7, ALL-1 |
| Ig Type | IgG1 |
| Clone | 8N714 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human KMT2A (AA:150-400) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | KMT2A |
| Gene ID | |
| Protein Name | Histone-lysine N-methyltransferase 2A |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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