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D-GsMTx4 TFA

Name: D-GsMTx4 TFA
Brand: TargetMol
SKU: T37697L
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37697L

D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.

D-GsMTx4 TFA

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Purity: 99.65%

Catalog No. T37697L

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$163	In Stock	In Stock
500 μg	$438	In Stock	In Stock
1 mg	$592	In Stock	In Stock
5 mg	$1,160	In Stock	In Stock
10 mg	$1,670	In Stock	In Stock
25 mg	$2,490	In Stock	In Stock
50 mg	$3,360	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	4216.93
Formula	C₁₈₇H₂₇₉F₃N₄₈O₄₈S₆
Smiles	[H]NCC(N[C@@H](CS)C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N6CCC[C@H]6C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N7CCC[C@H]7C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CC=CC=C8)C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC9=CC=CC=C9)C(N[C@H](C(N[C@@H](CC%10=CC=CC=C%10)C(O)=O)=O)CO)=O)=O)CC(N)=O)=O)=O)CC(C)C)=O)CCCCN)=O)=O)CC(C)C)=O)CCCCN)=O)CO)=O)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)=O)=O)CCCCN)=O)=O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)=O)CCCCN)=O)=O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O.OC(C(F)(F)F)=O
Relative Density.	no data available
Sequence	Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2 (Disulfide bridge:Cys2-Cys17, Cys9-Cys23, Cys16-Cys30)
Sequence Short	GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF(Modifications: All aminoacids = D-aminoacids, Disulfide bridges: 2-17, 9-23, 16-30, Phe-34 = C-terminal amide)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (59.28 mM)

H2O: 36 mg/mL (8.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (0.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2371 mL	1.1857 mL	2.3714 mL	11.8570 mL
5 mM	0.0474 mL	0.2371 mL	0.4743 mL	2.3714 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.0237 mL	0.1186 mL	0.2371 mL	1.1857 mL
20 mM	0.0119 mL	0.0593 mL	0.1186 mL	0.5928 mL
50 mM	0.0047 mL	0.0237 mL	0.0474 mL	0.2371 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc