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D-GsMTx4 TFA

Name: D-GsMTx4 TFA
Brand: TargetMol
SKU: T37697L
Price: 438 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T37697L

D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.

D-GsMTx4 TFA

🥰Excellent

Purity: 99.65%

Catalog No. T37697L

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$438	In Stock	In Stock
1 mg	$633	In Stock	In Stock
5 mg	$1,320	In Stock	In Stock
10 mg	$1,780	In Stock	In Stock
25 mg	$2,650	In Stock	In Stock
50 mg	$3,570	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.65%

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	4216.93
Formula	C₁₈₇H₂₇₉F₃N₄₈O₄₈S₆
Smiles	[H]NCC(N[C@@H](CS)C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N6CCC[C@H]6C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N7CCC[C@H]7C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CC=CC=C8)C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC9=CC=CC=C9)C(N[C@H](C(N[C@@H](CC%10=CC=CC=C%10)C(O)=O)=O)CO)=O)=O)CC(N)=O)=O)=O)CC(C)C)=O)CCCCN)=O)=O)CC(C)C)=O)CCCCN)=O)CO)=O)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)=O)=O)CCCCN)=O)=O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)=O)CCCCN)=O)=O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O.OC(C(F)(F)F)=O
Relative Density.	no data available
Sequence	Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2 (Disulfide bridge:Cys2-Cys17, Cys9-Cys23, Cys16-Cys30)
Sequence Short	GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF(Modifications: All aminoacids = D-aminoacids, Disulfide bridges: 2-17, 9-23, 16-30, Phe-34 = C-terminal amide)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (59.28 mM)

H2O: 36 mg/mL (8.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (0.78 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2371 mL	1.1857 mL	2.3714 mL	11.8570 mL
5 mM	0.0474 mL	0.2371 mL	0.4743 mL	2.3714 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.0237 mL	0.1186 mL	0.2371 mL	1.1857 mL
20 mM	0.0119 mL	0.0593 mL	0.1186 mL	0.5928 mL
50 mM	0.0047 mL	0.0237 mL	0.0474 mL	0.2371 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc