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Anti-ER-alpha Monoclonal Antibody (1X353)
(Synonyms: ESRA, ESR1, Era, ER) Copy Product Info
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Synonyms: ESRA, ESR1, Era, ER
Catalog No. TMAT-0672 Copy Product Info
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Anti-ER-alpha Monoclonal Antibody (1X353) is a Mouse antibody targeting ER-alpha. Anti-ER-alpha Monoclonal Antibody (1X353) can be used in WB,IHC.
Anti-ER-alpha Monoclonal Antibody
(1X353)
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-ER-alpha Monoclonal Antibody (1X353) is a Mouse antibody targeting ER-alpha. Anti-ER-alpha Monoclonal Antibody (1X353) can be used in WB,IHC. |
| Synonyms | ESRA, ESR1, Era, ER |
| Ig Type | IgG1 |
| Clone | 1X353 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | ESR1 |
| Gene ID | |
| Protein Name | Estrogen receptor |
| Uniprot ID |
| Molecular Weight | Theoretical: 66.2 kDa |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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