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Anti-CHRNA7 Monoclonal Antibody (3E741)
(Synonyms: NACHRA7, CHRNA7-2) Copy Product Info
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Synonyms: NACHRA7, CHRNA7-2
Catalog No. TMAT-1001 Copy Product Info
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Anti-CHRNA7 Monoclonal Antibody (3E741) is a Mouse antibody targeting CHRNA7. Anti-CHRNA7 Monoclonal Antibody (3E741) can be used in WB,FCM.
Anti-CHRNA7 Monoclonal Antibody
(3E741)
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-CHRNA7 Monoclonal Antibody (3E741) is a Mouse antibody targeting CHRNA7. Anti-CHRNA7 Monoclonal Antibody (3E741) can be used in WB,FCM. |
| Synonyms | NACHRA7, CHRNA7-2 |
| Ig Type | IgG1 |
| Clone | 3E741 |
| Reactivity | Human,Rat |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human CHRNA7 (AA: extra 52-259) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | CHRNA7 |
| Gene ID | |
| Protein Name | Neuronal acetylcholine receptor subunit alpha-7 |
| Uniprot ID |
| Molecular Weight | Theoretical: 56.4 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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