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Anti-PTPN11 Monoclonal Antibody (8Q534)

(Synonyms: SH-PTP3, SH-PTP2, SHP2, PTP2C, PTP-1D, NS1, MGC14433, CFC, BPTP3) Copy Product Info
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Synonyms: SH-PTP3, SH-PTP2, SHP2, PTP2C, PTP-1D, NS1, MGC14433, CFC, BPTP3

Catalog No. TMAT-1227 Copy Product Info
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Anti-PTPN11 Monoclonal Antibody (8Q534) is a Mouse antibody targeting PTPN11. Anti-PTPN11 Monoclonal Antibody (8Q534) can be used in IHC,IF,FCM.

Anti-PTPN11 Monoclonal Antibody
(8Q534)

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Product Introduction

Bioactivity
Description
Anti-PTPN11 Monoclonal Antibody (8Q534) is a Mouse antibody targeting PTPN11. Anti-PTPN11 Monoclonal Antibody (8Q534) can be used in IHC,IF,FCM.
SynonymsSH-PTP3, SH-PTP2, SHP2, PTP2C, PTP-1D, NS1, MGC14433, CFC, BPTP3
Ig Type
IgG1
Clone
8Q534
Reactivity
Human
Application
Recommended Dose
IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationPBS with 0.05% sodium azide
Concentration1 mg/mL
Research BackgroundThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. Coli.
Antigen Species
Human
Gene Name
PTPN11
Gene ID
Protein Name
Tyrosine-protein phosphatase non-receptor type 11
Uniprot ID
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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