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Anti-RELB Monoclonal Antibody (7A700)
(Synonyms: REL-B, I-REL, IREL) Copy Product Info
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Synonyms: REL-B, I-REL, IREL
Catalog No. TMAT-1191 Copy Product Info
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Anti-RELB Monoclonal Antibody (7A700) is a Mouse antibody targeting RELB. Anti-RELB Monoclonal Antibody (7A700) can be used in IHC,IF,FCM.
Anti-RELB Monoclonal Antibody
(7A700)
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| Description | Anti-RELB Monoclonal Antibody (7A700) is a Mouse antibody targeting RELB. Anti-RELB Monoclonal Antibody (7A700) can be used in IHC,IF,FCM. |
| Synonyms | REL-B, I-REL, IREL |
| Ig Type | IgG2a |
| Clone | 7A700 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human RELB (AA: 273-443) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | RELB |
| Gene ID | |
| Protein Name | Transcription factor RelB |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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