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Anti-HLA-DRB1 Monoclonal Antibody (3O58)
(Synonyms: SS1, HLA-DRB, HLA-DR1B, DRB1) Copy Product Info
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Synonyms: SS1, HLA-DRB, HLA-DR1B, DRB1
Catalog No. TMAT-0649 Copy Product Info
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Anti-HLA-DRB1 Monoclonal Antibody (3O58) is a Mouse antibody targeting HLA-DRB1. Anti-HLA-DRB1 Monoclonal Antibody (3O58) can be used in WB,IHC,FCM.
Anti-HLA-DRB1 Monoclonal Antibody
(3O58)
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-HLA-DRB1 Monoclonal Antibody (3O58) is a Mouse antibody targeting HLA-DRB1. Anti-HLA-DRB1 Monoclonal Antibody (3O58) can be used in WB,IHC,FCM. |
| Synonyms | SS1, HLA-DRB, HLA-DR1B, DRB1 |
| Ig Type | IgG1 |
| Clone | 3O58 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human HLA-DRB1 (AA: 30-266) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | HLA-DRB1 |
| Gene ID | |
| Protein Name | HLA class II histocompatibility antigen, DRB1 beta chain |
| Uniprot ID |
| Molecular Weight | Theoretical: 29.9 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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