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Anti-PTPN1 Monoclonal Antibody (5I181)
(Synonyms: PTP1B) Copy Product Info
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Synonyms: PTP1B
Catalog No. TMAT-0879 Copy Product Info
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Anti-PTPN1 Monoclonal Antibody (5I181) is a Mouse antibody targeting PTPN1. Anti-PTPN1 Monoclonal Antibody (5I181) can be used in WB,IHC,IF,FCM.
Anti-PTPN1 Monoclonal Antibody
(5I181)
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-PTPN1 Monoclonal Antibody (5I181) is a Mouse antibody targeting PTPN1. Anti-PTPN1 Monoclonal Antibody (5I181) can be used in WB,IHC,IF,FCM. |
| Synonyms | PTP1B |
| Ig Type | IgG1 |
| Clone | 5I181 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human PTPN1 (AA: 40-246) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | PTPN1 |
| Gene ID | |
| Protein Name | Tyrosine-protein phosphatase non-receptor type 1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 50 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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