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Anti-MCL1 Monoclonal Antibody (5E149)
(Synonyms: TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3) Copy Product Info
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Synonyms: TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3
Catalog No. TMAT-1239 Copy Product Info
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Anti-MCL1 Monoclonal Antibody (5E149) is a Mouse antibody targeting MCL1. Anti-MCL1 Monoclonal Antibody (5E149) can be used in WB,IHC,IF.
Anti-MCL1 Monoclonal Antibody
(5E149)
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| Description | Anti-MCL1 Monoclonal Antibody (5E149) is a Mouse antibody targeting MCL1. Anti-MCL1 Monoclonal Antibody (5E149) can be used in WB,IHC,IF. |
| Synonyms | TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3 |
| Ig Type | IgG1 |
| Clone | 5E149 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene thatincreased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human MCL-1 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MCL1 |
| Gene ID | |
| Protein Name | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 37 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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