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Anti-MAP3K5 Monoclonal Antibody (4H549)
(Synonyms: MEKK5, MAPKKK5, ASK1) Copy Product Info
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Synonyms: MEKK5, MAPKKK5, ASK1
Catalog No. TMAT-1507 Copy Product Info
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Anti-MAP3K5 Monoclonal Antibody (4H549) is a Mouse antibody targeting MAP3K5. Anti-MAP3K5 Monoclonal Antibody (4H549) can be used in IHC,IF,FCM.
Anti-MAP3K5 Monoclonal Antibody
(4H549)
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-MAP3K5 Monoclonal Antibody (4H549) is a Mouse antibody targeting MAP3K5. Anti-MAP3K5 Monoclonal Antibody (4H549) can be used in IHC,IF,FCM. |
| Synonyms | MEKK5, MAPKKK5, ASK1 |
| Ig Type | IgG1 |
| Clone | 4H549 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human MAP3K5 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MAP3K5 |
| Gene ID | |
| Protein Name | Mitogen-activated protein kinase kinase kinase 5 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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