en

EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzyme-selective compound with potential anti-androgenic and anti-tumor activity.

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

[4-(5,7-dihydroxy-6-methylidenehept-1-en-2-yl)-6-hydroxycyclohex-1-en-1-yl]methyl 2-methylpropanoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1S,4aS,5S)-1,4a-dimethyl-6-methylidene-5-[(1E)-3-oxobut-1-en-1-yl]-decahydronaphthalene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-3-[3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]phenol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2Z,6E)-6-methyl-8-(3-methyl-5-oxo-2,5-dihydrofuran-2-yl)-2-(4-methylpent-3-en-1-yl)octa-2,6-dienoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

8-(2-methoxy-3-methyl-5-oxo-2,5-dihydrofuran-2-yl)-6-methyl-2-(4-methylpent-3-en-1-yl)octa-2,6-dienoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

11-hydroxy-12a-methyl-10-methylidene-3-(prop-1-en-2-yl)-tetradecahydrocyclopenta[11]annulene-6-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(7E)-10-hydroxy-12-(methoxymethyl)-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{[4-methyl-1-(propan-2-yl)cyclohex-3-en-1-yl]oxy}oxane-3,4,5-triol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6-{2-hydroxy-4-methyl-6-[(1E)-3-oxobut-1-en-1-yl]phenoxy}-2-methoxy-3-(1-methoxy-3-methylbutyl)benzoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-{[4-(4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)butan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

7-[(1E)-2-carboxyeth-1-en-1-yl]-3-(3,4-dihydroxyphenyl)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl 2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

9-(acetyloxy)-3,6,6,13-tetramethyl-12-oxotetracyclo[11.2.1.0^{1,10}.0^{2,7}]hexadec-2-en-8-yl benzoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-{2-[(2Z)-pent-2-en-1-yl]-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclopentyl}acetic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-{2-[(3Z)-3-(hydroxymethyl)-7-oxooct-3-en-1-yl]-3-(2-hydroxypropan-2-yl)-1-methylcyclopentyl}acetic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

4-amino-2-hydroxy-4-[(1-hydroxy-1-{2-oxobicyclo[4.1.0]hept-3-en-1-yl}propan-2-yl)carbamoyl]butanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-en-1-yl)-4H,8H-pyrano[2,3-f]chromen-4-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-(hydroxymethyl)-6-({3,4,5-trihydroxy-6-[4-(prop-2-en-1-yl)phenoxy]oxan-2-yl}methoxy)oxane-3,4,5-triol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-{6-acetyl-3-[(2-methylpropanoyl)oxy]-2,3-dihydro-1-benzofuran-2-yl}prop-2-en-1-yl 2-methylpropanoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1S,5R,6S)-5-(acetyloxy)-3-(hydroxymethyl)-4-oxo-6-(propan-2-yl)cyclohex-2-en-1-yl (2E)-2-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[(3Z)-5-hydroxy-3-methylpent-3-en-1-yl]-1,4a-dimethyl-6-methylidene-decahydronaphthalene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.