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EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzyme-selective compound with potential anti-androgenic and anti-tumor activity.

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

Chol-5-en-24-al-3β-ol, a steroid compound, exhibits properties characteristic of steroids.

EN40, as a covalent ligand, is a selective inhibitor of aldehyde dehydrogenase 3A1 (IC50: 2 uM).

EN460 is a selective inhibitor of Endoplasmic Reticulum Oxidase 1 (ERO1α), inhibiting ERO1L-mediated gene silencing and cell migration, and PDAC invasion.

16-Hydroxylup-20(29)-en-3-one is a bioactive chemical.

3-Hydroxy-(28-4-coumaroyloxy)lup-20(29)-en-27-oic acid is from stem bark & twigs of Caraipa densifolia Mart. (Theaceae).

3-Hydroxylup-20(29)en-23,28-dioic acid is a bioactive chemical.

EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114 and binds specifically to cysteine 8 (C8) within its intrinsically disordered region, exhibiting an IC50 of 470 nM. EN219 inhibits RNF114-induced autoubiquitination and p21 ubiquitination in cell-free assays at 50 μM. At 1 μM, EN219 interacts with multiple proteins including the tubulin β1 chain (TUBB1), heat shock protein 60 (Hsp60/HspD1), and histone H3.1 (HIST1H3A) in 231MFP breast cancer cells. Furthermore, EN219 has been linked to the bromodomain inhibitor (+)-JQ1 for the creation of a PROTAC capable of degrading BRD4 in 231MFP cells.

17,17-(Ethylenedioxy)androst-4-en-3-one (4-androstene-3,17-dione-17-cyclic ethylene ketal) is an effective ingredient in cosmetics, utilized in acne treatment and hair growth research. It inhibits reductase activity and prevents the binding of a receptor protein with 5α-DHT.

7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid, a ganoderma triterpenoid found in Ganoderma Lucidum Karst, is acknowledged as a significant bioactive ingredient and can be employed in the investigation of different etiologies.

EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.

EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one is a natural product

1,7-Bis(4-hydroxyphenyl)hept-6-en-3-one is a natural product for research related to life sciences. The catalog number is TN2514 and the CAS number is 1251830-57-5.

1-Oxo-4-hydroxy-2-en-4-ethylcyclohexa-5,8-olide is a natural product used in life sciences research (catalog number: TN2561, CAS number: 55604-88-1).

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o

3,22-Dihydroxyolean-12-en-29-oic acid is a natural product for research related to life sciences. The catalog number is TN2860 and the CAS number is 808769-54-2.

7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB) is a natural product for research related to life sciences. The catalog number is TN3217 and the CAS number is 79559-60-7.

(3E)-4-(1H-indol-3-yl)but-3-en-2-one ((E)-4-(1H-indol-3-yl)but-3-en-2-one) is a marine derived natural products found in Tedania (Tedania) ignis.

3β,7β,15α-Trihydroxy-4-(hydroxymethyl)-11,23-dioxo-lanost-8-en-26-oic acid is a triterpene compound found in Ganoderma lucidum, known for its inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglial cells, with an IC50 of 4.15 μM.

3-(4-Methylpent-3-en-1-yl)pent-2-enedioyl-CoA (3-(4-Methylpent-3-en-1-yl)pent-2-enedioyl-coenzyme A) is a type of 2-enoyl-CoA.

3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA (3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-coenzyme A) is a derivative of coenzyme A.

3,22-Diketochol-4-en-24-oyl-CoA (3,22-Dioxochol-4-en-24-oyl-coenzyme A) is a steroid acyl coenzyme A.