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Anti-inflammatory agent 86

Name: Anti-inflammatory agent 86
Brand: TargetMol
SKU: T210061
Rating: 4.5 (1 reviews)

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Catalog No. T210061

Anti-inflammatory agent 86 is a derivative of Chrysin with anti-inflammatory properties. It inhibits TNF-α-induced monocyte adhesion to colon epithelium, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 shows potential for use in inflammatory bowel disease (IBD) research.

Anti-inflammatory agent 86

🥰Excellent

Catalog No. T210061

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Product Introduction

Bioactivity

Description	Anti-inflammatory agent 86 is a derivative of Chrysin with anti-inflammatory properties. It inhibits TNF-α-induced monocyte adhesion to colon epithelium, with an IC50 of 4.71 μM. Anti-inflammatory agent 86 shows potential for use in inflammatory bowel disease (IBD) research.
In vitro	Anti-inflammatory agent 86 (Compound 4b) significantly inhibits TNF-α-induced monocyte adhesion to HT-29 cells, with an IC₅₀ of 4.71 μM. At concentrations of 5-10 μM over 4 hours, it markedly suppresses MCP-1 expression in a concentration-dependent manner. Additionally, Anti-inflammatory agent 86 inhibits NF-κB activity and TNF-α-induced ROS production in a dose-dependent manner in HT-29 cells.
In vivo	The compound, referred to as Anti-inflammatory agent 86 (30-60 mg/kg; oral administration; once daily; for 15 consecutive days), demonstrates the most significant efficacy in treating TNBS-induced colitis.

Chemical Properties

Formula

C₂₉H₃₄N₂O₅S₂

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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