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5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
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Catalog No. TN3084Cas No. 1353676-65-9
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone demonstrated a strong anti-proliferative effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 μM. It significantly down-regulated the expression of estrogen receptor-α (ER-α) and inhibited tumor growth in the BCAP-37 human breast cancer cell line xenograft model.
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
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Catalog No. TN3084Cas No. 1353676-65-9
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone demonstrated a strong anti-proliferative effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 μM. It significantly down-regulated the expression of estrogen receptor-α (ER-α) and inhibited tumor growth in the BCAP-37 human breast cancer cell line xenograft model.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $1,920 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $2,280 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:Yellow
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| Description | 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone demonstrated a strong anti-proliferative effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 μM. It significantly down-regulated the expression of estrogen receptor-α (ER-α) and inhibited tumor growth in the BCAP-37 human breast cancer cell line xenograft model. |
| In vitro | We found that 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro (with an IC50 of 4.41 μM).[1] |
| In vivo | We found that 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.[1] |
| Molecular Weight | 452.5 |
| Formula | C26H28O7 |
| Cas No. | 1353676-65-9 |
| Smiles | O=C1C(OC)=C(OC=2C1=C(O)C=C(O)C2CC=C(C)C)C=3C=C(O)C(O)=C(C3)CC=C(C)C |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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