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Dioxybenzone

Name: Dioxybenzone
Brand: TargetMol
SKU: T0698
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0698Cas No. 131-53-3

Alias UV-24, Dioxybenzon, Cyasorb UV 24, Benzophenone-8, Advastab 47, 2,2'-Dihydroxy-4-methoxybenzophenone

Dioxybenzone (Benzophenone-8) is an organic agent that blocks UVB and short-wave UVA ultraviolet radiation.

Dioxybenzone

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Purity: 99.39%

Catalog No. T0698Alias UV-24, Dioxybenzon, Cyasorb UV 24, Benzophenone-8, Advastab 47, 2,2'-Dihydroxy-4-methoxybenzophenoneCas No. 131-53-3

Dioxybenzone (Benzophenone-8) is an organic agent that blocks UVB and short-wave UVA ultraviolet radiation.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$42	In Stock	In Stock
1 g	$58	-	In Stock
2 g	$82	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Dioxybenzone AI Summary

Dioxybenzone exhibits a broad spectrum of bioactivities across various assays. It demonstrates potency as a modulator of Lamin A splicing, inhibitors and substrates of Cytochrome P450 enzymes (2C19 and 3A4), and both agonists and antagonists of the Hypoxia Response Element Signaling Pathway. It acts as an inhibitor of enzymes such as HPGD and 15-human lipoxygenase and activates Cytochrome P450 3A4. It also shows activity against the malarial parasite plastid, delayed death inhibitors, DNA re-replication in colon adenocarcinoma cells, human tyrosyl-DNA phosphodiesterase 1 (TDP-43), and various viral entry blockers. Additionally, Dioxybenzone is effective in inhibiting sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 87.65% and 85.43% at 10 µM, respectively. The compound exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells with an inhibition rate of 11.04% at a 10 µM concentration after 48 hours. It also demonstrates 7.352% inhibition of the SARS-CoV-2 3CL-Pro protease at a 20 µM concentration. However, its inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 shows a lower activity with an inhibition index of 0.507 relative to the arbidol control. Dioxybenzone shows inhibition of the human HDAC6 enzyme activity with 8.93% and 6.28% inhibition in enzymatic assays using commercial and custom peptide substrates, respectively. It further exhibits binding affinity towards receptors like SLC6A2 and ADORA3, antagonistic activity at human TBXA2R and CHRM1, and agonistic activity at human HTR2B and ADRA1A receptors. In summary, Dioxybenzone displays inhibitory, binding, antagonistic, and agonistic properties across various biological targets and assays, indicating its potential for diverse therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dioxybenzone (Benzophenone-8) is an organic agent that blocks UVB and short-wave UVA ultraviolet radiation.
Synonyms	UV-24, Dioxybenzon, Cyasorb UV 24, Benzophenone-8, Advastab 47, 2,2'-Dihydroxy-4-methoxybenzophenone

Chemical Properties

Molecular Weight	244.24
Formula	C₁₄H₁₂O₄
Cas No.	131-53-3
Smiles	C(=O)(C1=C(O)C=C(OC)C=C1)C2=C(O)C=CC=C2
Relative Density.	1.296 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 45 mg/mL (184.25 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 65 mg/mL (266.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0943 mL	20.4717 mL	40.9433 mL	204.7167 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL	40.9433 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL	20.4717 mL
20 mM	0.2047 mL	1.0236 mL	2.0472 mL	10.2358 mL
50 mM	0.0819 mL	0.4094 mL	0.8189 mL	4.0943 mL
100 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0472 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc